The Real Lisp Curse is performance. If it was winning benchmarks its ugly syntax would be forgiven. But with lackluster performance and ugly syntax it won't be. It doesn't have a niche like JavaScript where its dominant and it doesn't appeal to newbie programmers like Python or Ruby. And to top it off many languages have absorbed the "killer features" of Lisp over the years, so the advantage of Lisp is shrinking every day.