GUIDs as keys in DB

Any reason not to do it? The most common arguments against I see are

It's 4x the size of an int

Storage space is basically free in 2021

It's cumbersome to debug

If you're typing ids by hand, you're doing things wrong

Fuck around, find out

>>2
I've been using them for 3 years with no adverse effects.

>>3
I tried them one time, and my dick fell off. 10/10 would buy again